Transdermal dopaminergic D2 receptor agonist therapy in Parkinson's disease with N‐0923 TDS: A double‐blind, placebo‐controlled study
Identifieur interne : 003159 ( Main/Exploration ); précédent : 003158; suivant : 003160Transdermal dopaminergic D2 receptor agonist therapy in Parkinson's disease with N‐0923 TDS: A double‐blind, placebo‐controlled study
Auteurs : J. Thomas Hutton [États-Unis] ; Leo Verhagen Metman [États-Unis] ; Thomas N. Chase [États-Unis] ; Jorge L. Juncos [États-Unis] ; William C. Koller [États-Unis] ; Rajesh Pahwa [États-Unis] ; Peter A. Lewitt [États-Unis] ; Ali Samii [Canada] ; Joseph K. C. Tsui [Canada] ; Donald B. Calne [Canada] ; Cheryl H. Waters [États-Unis] ; Vincent P. Calabrese [États-Unis] ; James P. Bennett [États-Unis] ; Richard Barrett [États-Unis] ; Jerry L. Morris [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2001-05.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
Abstract
N‐0923 is a non‐ergot, dopaminergic D2 agonist designed to be transdermally available. It has anti‐parkinsonian effects when infused intravenously. An adhesive matrix patch was developed to deliver N‐0923 transdermally (N‐0923 TDS). In this phase II trial, we evaluated the effectiveness of various doses of N‐0923 TDS at replacing levodopa. Eighty‐five Parkinson's disease (PD) patients were randomized to placebo or one of four doses of N‐0923 TDS for 21 days. Change in daily levodopa dose was the primary efficacy measure. Significantly greater reductions in levodopa dose were achieved as compared to placebo for the two highest doses of N‐0923 TDS. Patients treated with 33.5 mg and 67 mg N‐0923 TDS decreased levodopa use by 26% and 28%, vs. 7% for placebo. N‐0923 TDS was safe and well tolerated. © 2001 Movement Disorder Society.
Url:
DOI: 10.1002/mds.1085
Affiliations:
- Canada, États-Unis
- Californie, Floride, Géorgie (États-Unis), Kansas, Maryland, Michigan, Texas, Virginie
- Los Angeles
- Université de Californie du Sud
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Le document en format XML
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Lewitt</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Clinical Neuroscience Center, Southfield, Michigan, and Department of Neurology, Psychiatry, and Behavioral Neuroscience, Wayne State University School of Medicine, Detroit, Michigan</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Samii, Ali" sort="Samii, Ali" uniqKey="Samii A" first="Ali" last="Samii">Ali Samii</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Vancouver Hospital & Health Sciences Center, University of British Columbia, Vancouver, British Columbia</wicri:regionArea><wicri:noRegion>British Columbia</wicri:noRegion></affiliation></author><author><name sortKey="Tsui, Joseph K C" sort="Tsui, Joseph K C" uniqKey="Tsui J" first="Joseph K. C." last="Tsui">Joseph K. C. 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Bennett</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University Of Virginia Medical Center, Charlottesville, Virginia</wicri:regionArea><placeName><region type="state">Virginie</region></placeName></affiliation></author><author><name sortKey="Barrett, Richard" sort="Barrett, Richard" uniqKey="Barrett R" first="Richard" last="Barrett">Richard Barrett</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Discovery Therapeutics, Inc., Richmond, Virginia</wicri:regionArea><placeName><region type="state">Virginie</region></placeName></affiliation></author><author><name sortKey="Morris, Jerry L" sort="Morris, Jerry L" uniqKey="Morris J" first="Jerry L." last="Morris">Jerry L. Morris</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Neurology Research & Education Center, Covenant Medical Center, Lubbock, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>John Wiley & Sons, Inc.</publisher><pubPlace>New York</pubPlace><date type="published" when="2001-05">2001-05</date><biblScope unit="volume">16</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="459">459</biblScope><biblScope unit="page" to="463">463</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">50AE8DB7CCB64ED806B059C388944B1E76B96689</idno><idno type="DOI">10.1002/mds.1085</idno><idno type="ArticleID">MDS1085</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Agonist</term><term>Chemotherapy</term><term>D2 Dopamine receptor</term><term>Double blind study</term><term>Human</term><term>N‐0923 transdermal</term><term>Parkinson disease</term><term>Parkinson's disease</term><term>Phase II trial</term><term>Transdermal system</term><term>Treatment</term><term>dopaminergic D2 agonist</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Agoniste</term><term>Chimiothérapie</term><term>Essai clinique phase II</term><term>Etude double insu</term><term>Homme</term><term>N-0923</term><term>Parkinson maladie</term><term>Récepteur dopaminergique D2</term><term>Système transdermique</term><term>Traitement</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">N‐0923 is a non‐ergot, dopaminergic D2 agonist designed to be transdermally available. It has anti‐parkinsonian effects when infused intravenously. An adhesive matrix patch was developed to deliver N‐0923 transdermally (N‐0923 TDS). In this phase II trial, we evaluated the effectiveness of various doses of N‐0923 TDS at replacing levodopa. Eighty‐five Parkinson's disease (PD) patients were randomized to placebo or one of four doses of N‐0923 TDS for 21 days. Change in daily levodopa dose was the primary efficacy measure. Significantly greater reductions in levodopa dose were achieved as compared to placebo for the two highest doses of N‐0923 TDS. Patients treated with 33.5 mg and 67 mg N‐0923 TDS decreased levodopa use by 26% and 28%, vs. 7% for placebo. N‐0923 TDS was safe and well tolerated. © 2001 Movement Disorder Society.</div></front></TEI><affiliations><list><country><li>Canada</li><li>États-Unis</li></country><region><li>Californie</li><li>Floride</li><li>Géorgie (États-Unis)</li><li>Kansas</li><li>Maryland</li><li>Michigan</li><li>Texas</li><li>Virginie</li></region><settlement><li>Los Angeles</li></settlement><orgName><li>Université de Californie du Sud</li></orgName></list><tree><country name="États-Unis"><region name="Texas"><name sortKey="Hutton, J Thomas" sort="Hutton, J Thomas" uniqKey="Hutton J" first="J. Thomas" last="Hutton">J. Thomas Hutton</name></region><name sortKey="Barrett, Richard" sort="Barrett, Richard" uniqKey="Barrett R" first="Richard" last="Barrett">Richard Barrett</name><name sortKey="Bennett, James P" sort="Bennett, James P" uniqKey="Bennett J" first="James P." last="Bennett">James P. Bennett</name><name sortKey="Calabrese, Vincent P" sort="Calabrese, Vincent P" uniqKey="Calabrese V" first="Vincent P." last="Calabrese">Vincent P. Calabrese</name><name sortKey="Chase, Thomas N" sort="Chase, Thomas N" uniqKey="Chase T" first="Thomas N." last="Chase">Thomas N. Chase</name><name sortKey="Juncos, Jorge L" sort="Juncos, Jorge L" uniqKey="Juncos J" first="Jorge L." last="Juncos">Jorge L. Juncos</name><name sortKey="Koller, William C" sort="Koller, William C" uniqKey="Koller W" first="William C." last="Koller">William C. Koller</name><name sortKey="Lewitt, Peter A" sort="Lewitt, Peter A" uniqKey="Lewitt P" first="Peter A." last="Lewitt">Peter A. Lewitt</name><name sortKey="Metman, Leo Verhagen" sort="Metman, Leo Verhagen" uniqKey="Metman L" first="Leo Verhagen" last="Metman">Leo Verhagen Metman</name><name sortKey="Morris, Jerry L" sort="Morris, Jerry L" uniqKey="Morris J" first="Jerry L." last="Morris">Jerry L. Morris</name><name sortKey="Pahwa, Rajesh" sort="Pahwa, Rajesh" uniqKey="Pahwa R" first="Rajesh" last="Pahwa">Rajesh Pahwa</name><name sortKey="Waters, Cheryl H" sort="Waters, Cheryl H" uniqKey="Waters C" first="Cheryl H." last="Waters">Cheryl H. Waters</name></country><country name="Canada"><noRegion><name sortKey="Samii, Ali" sort="Samii, Ali" uniqKey="Samii A" first="Ali" last="Samii">Ali Samii</name></noRegion><name sortKey="Calne, Donald B" sort="Calne, Donald B" uniqKey="Calne D" first="Donald B." last="Calne">Donald B. Calne</name><name sortKey="Tsui, Joseph K C" sort="Tsui, Joseph K C" uniqKey="Tsui J" first="Joseph K. C." last="Tsui">Joseph K. C. Tsui</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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